Journal Reviews

The effect of everolimus on retinal pigment epithelium and proliferative vitreo-retinopathy

1 August 2018 | | Retina / Uvea / Vitreous | Everolimus, mammalian target of rapamycin (mTOR), proliferative vitreoretinopathy, retinal detachment, ribosomal protein S6 (RPS6)

The principal cells involved in proliferative vitreo-retinopathy (PVR) are retinal pigment epithelial cells (RPE). Everolimus is a drug used in renal cell carcinoma which targets and inhibits a key regulatory protein in cancer (mTOR). In this study, the authors investigated...